VertexPharmaceuticals2025JPMPresentationPDF

global.vrtx.comJ.P. MORGAN HEALTHCARE CONFERENCEJANUARY 2025RESHMA KEWALRAMANI, M.D.CEO AND PRESIDENT©2025 Vertex Pharmaceuticals IncorporatedSAFE HARBOR STATEMENT & NON-GAAP FINANCIAL MEASURESThis presentation contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, including, without limitation, the information provided regarding futurefinancial and operating performance and statements regarding (i) expectations, development plans and timelines for the company’s products, product candidates and pipeline programs, including expectations that we are on track to complete five launches in five years, that we have pipeline diversification across diseases and geographies with pipeline opportunities across multiple multi-billion dollar markets, and the anticipated benefits of new products andregarding relevant patient populations, (ii) expectations for uptake of and expanded access to our products, (iii) expectations for sustained and profitabl