IONIS2025JPMPresentation_FINAL

The Next Chapter: Accelerating Value Through InnovationBrett P. Monia, Ph.D., Chief Executive Officer JP Morgan Healthcare Conference | January 2025 | Nasdaq: IONSForward-Looking StatementsThis presentation includes forward-looking statements regarding our business, financial guidance and the therapeutic and commercial potential of our commercial medicines, additional medicines in development and technologies. Any statement describing Ionis’ goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties including but not limited to those related to our commercial products and the medicines in our pipeline, and particularly those inherent in the process of discovering, developing and commercializing medicines that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such medicines. Ion