PFAS风险评估和毒理学研究

Kurt GustEnvironmental Laboratory (EL)USACE Engineer Research & Development CenterE-mail: kurt.a.gust@usace.army.milPhone: 601-634-3593PFOS Bioaccumulation and Bioconcentration Factors in Multi-Generational Zebrafish ExposuresDisclaimer StatementThe contents of this presentation neither constitute nor necessarily reflect DOD policy.AcknowledgementsResearch Team:Ashley N. KimbleJ. Erik MylroieMichael L. MayoMitch S. WilbanksCatherine S. C. StewardKacy A. ChapmanGuilherme R. LotufoNatalia Garcia-ReyeroDavid W. MooreSponsors:▪SERDP ESTCP▪Sediment Management Work Group (SMWG)** Select membersBackgroundPer-and polyfluoroalkyl substances (PFAS) pose exposure risks to diverse ecological systems and to humans. The PFAS, perfluorooctanesulfonic acid (PFOS), is broadly distributed in surface waters and is toxic to a variety of aquatic organisms including fish.A need exists to understand how PFOS bioaccumulates in aquatic exposures.In the Present Study•We determined how exposure concentrations,